GLS1 Inhibitor-4
Product Specifications
CAS Number
2768599-97-7
Target
Glutaminase, Apoptosis
Related Pathways
Apoptosis, Proteases/Proteasome
Bioactivity
GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM, exhibiting antiproliferative effects, substantial metabolic stability, and strong GLS1 binding affinity. It disrupts glutamine metabolism, induces ROS production, triggers apoptosis, and demonstrates notable antitumor activity [1].
Smiles
C1CN(CCC1NC2=NN=C(S2)NC(=O)CC3=CC=CC=C3)C4=NN=C(S4)NC(=O)C5=NC=CN5CC6=CC=C(C=C6)C(F)(F)F
Molecular Formula
C29H27F3N10O2S2
Molecular Weight
668.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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