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NMDAR/TRPM4-IN-2

Product Specifications

CAS Number

2243506-33-2

Target

TRP/TRPV Channel, iGluR, ERK, NMDAR

Related Pathways

Membrane transporter/Ion channel, Neuroscience, MAPK

Purity

0.9975

Bioactivity

NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mitochondrial dysfunction. NMDAR/TRPM4-IN-2 showed neuroprotective activity against NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons with an IC50 value of 2.1 μM.

Smiles

Cl.Cl.CCN(CCN)Cc1cccc(Br)c1

Molecular Formula

C11H19BrCl2N2

Molecular Weight

330.092

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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