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CRIPGBM chloride

Product Specifications

CAS Number

2361988-77-2

Target

Caspase, Apoptosis, RIP kinase

Related Pathways

Apoptosis, NF-κB, Proteases/Proteasome

Purity

0.9975

Bioactivity

CRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.

Smiles

[Cl-].O=C1C=2C=CC=CC2C(=O)C3=C1N(C(=[N+]3CC4=CC=C(F)C=C4)C)CC=5C=CC=CC5

Molecular Formula

C26H20ClFN2O2

Molecular Weight

446.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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