CRIPGBM chloride
Product Specifications
CAS Number
2361988-77-2
Target
Caspase|||Apoptosis|||RIP kinase
Related Pathways
Apoptosis|||NF-?B|||Proteases/Proteasome
Purity
0.9975
Bioactivity
CRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.
Smiles
[Cl-].O=C1C=2C=CC=CC2C(=O)C3=C1N(C(=[N+]3CC4=CC=C(F)C=C4)C)CC=5C=CC=CC5
Molecular Formula
C26H20ClFN2O2
Molecular Weight
446.9
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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