A2AR-antagonist-1
Product Specifications
CAS Number
2922920-71-4
Target
Adenosine Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Bioactivity
A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min) . Additionally, it activates T cells by inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and promoting expression of effector molecules (GZMB, IFNG, and IL-2) [1].
Smiles
CC1=C(C=CC=C1C2=NC(=NC(=C2)C3=CC(=O)N(C=C3)CC4=CC(=CC=C4)C(C)(C)O)N)C#N
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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