GCGR antagonist 2
Product Specifications
CAS Number
280134-25-0
Target
Glucagon Receptor, Others
Related Pathways
Others, GPCR/G Protein
Bioactivity
GCGR Antagonist 2, a Furan-2-carbohydrazide, serves as an orally active antagonist of the glucagon receptor. It exhibits affinity for the human glucagon receptor (hGluR) with a dissociation constant (Kd) of 2.3 nM and demonstrates inhibitory activity against the rat receptor with a half-maximal inhibitory concentration (IC50) of 0.43 nM. Additionally, this compound effectively prevents glucagon-stimulated glycogenolysis.
Smiles
C(N1C=2C(=C(C=NNC(=O)C3=CC(C#N)=C(O)C=C3)C=CC2)C=C1)C4=C(C)C(C)=CC(C)=C4C
Molecular Formula
C28H26N4O2
Molecular Weight
450.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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