Broussochalcone A
Product Specifications
CAS Number
99217-68-2
Target
Reactive Oxygen Species, Apoptosis, NR4A, FOXO, ROS, Xanthine Oxidase
Related Pathways
NF-κB, Apoptosis, Endocrinology/Hormones, Immunology/Inflammation, Metabolism
Purity
0.9746
Bioactivity
Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 μM) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.
Smiles
C(/C=C/C1=CC(O)=C(O)C=C1)(=O)C2=CC(CC=C(C)C)=C(O)C=C2O
Molecular Formula
C20H20O5
Molecular Weight
340.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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