Broussochalcone A

Product Specifications

CAS Number

99217-68-2

Target

Reactive Oxygen Species|||Apoptosis|||NR4A|||FOXO|||ROS|||Xanthine Oxidase

Related Pathways

NF-?B|||Apoptosis|||Endocrinology/Hormones|||Immunology/Inflammation|||Metabolism

Purity

0.9746

Bioactivity

Broussochalcone A is a natural antioxidant and xanthine oxidase inhibitor (IC50 = 2.21 ?M) that scavenges free radicals, inhibits iron-induced lipid peroxidation, and reduces nitric oxide synthesis in LPS-activated macrophages. Broussochalcone A induces apoptosis in human renal carcinoma cells by increasing ROS levels and activating the FOXO3 signaling pathway. Broussochalcone A is also a novel NR4A1 inhibitor that induces apoptosis in pancreatic cancer cells through NR4A1-dependent pathways.