Lapatinib tosylate
Product Specifications
CAS Number
1187538-35-7
Target
Autophagy, EGFR, Ferroptosis, Others
Related Pathways
Apoptosis, JAK/STAT signaling, Autophagy, Angiogenesis, Others, Tyrosine Kinase/Adaptors
Bioactivity
Lapatinib tosylate (GW572016), a robust and orally administered inhibitor specifically targeting the tyrosine kinase domains of ErbB-2 and EGFR, exhibits inhibitory concentration 50 (IC50) values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively.
Smiles
O=S(=O)(O)C1=CC=C(C=C1)C.O=S(=O)(C)CCNCC=1OC(=CC1)C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2
Molecular Formula
C36H34ClFN4O7S2
Molecular Weight
753.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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