Antitumor agent-81
Product Specifications
CAS Number
2765180-17-2
Target
Others, E1/E2/E3 Enzyme, p62, Apoptosis
Related Pathways
Apoptosis, Autophagy, Others, Ubiquitination
Bioactivity
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.
Smiles
O(C)C=1C=C(N2C=C(N=N2)C3=CC4=C(C=C3)N=C(N)N=C4N)C=C(OC)C1OC
Molecular Formula
C19H19N7O3
Molecular Weight
393.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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