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GPR84 antagonist 2

Product Specifications

CAS Number

2244269-74-5

Target

GPCR, Others

Related Pathways

GPCR/G Protein, Endocrinology/Hormones, Others

Bioactivity

GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.

Smiles

O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)[O-].[Na+]

Molecular Formula

C28H16Cl2NaO4PS2

Molecular Weight

605.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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