Umbralisib sulfate
Product Specifications
CAS Number
1532533-75-7
Target
Casein Kinase, Others, PI3K
Related Pathways
Others, Metabolism, PI3K/Akt/mTOR signaling, Stem Cells
Bioactivity
Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. It demonstrates unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) and is applicable in the research of hematological malignancies.
Smiles
S(=O)(=O)(O)O.NC1=C2C(=NN([C@@H](C)C3=C(C(=O)C=4C(O3)=CC=C(F)C4)C5=CC(F)=CC=C5)C2=NC=N1)C6=CC(F)=C(OC(C)C)C=C6
Molecular Formula
C31H26F3N5O7S
Molecular Weight
669.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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