Aurora kinase-IN-1
Product Specifications
Target
Apoptosis, Aurora Kinase, Others
Related Pathways
Cell Cycle/Checkpoint, Others, Apoptosis, Chromatin/Epigenetic
Bioactivity
Aurora kinase-IN-1, a potent aurora kinase inhibitor, modulates cell cycle progression and induces apoptosis by upregulating G1 cell cycle inhibitory proteins (including p21 and p27), elevating G1 progressive cyclin D1, and downregulating G1-to-S progressive cyclins, thereby arresting the cell cycle at the G1/S boundary. It stands as a promising lead compound for the development of chemotherapeutic agents.
Smiles
CCOC1/C(=C/NC2=NC(=CC(=N2)C3=CC(=C(C=C3)OC)OC)C4=CC=C(C=C4)Br)/C(=O)C5=C(O1)C=CC(=C5)Br
Molecular Formula
C30H25Br2N3O5
Molecular Weight
667.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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