THZ1 Hydrochloride

Product Specifications

Target

Others|||CDK

Related Pathways

Others|||Cell Cycle/Checkpoint

Bioactivity

THZ1 Hydrochloride is a potent, selective covalent inhibitor of CDK7, exhibiting an IC50 value of 3.2 nM. It also targets closely related kinases CDK12 and CDK13, leading to the downregulation of MYC expression.

Smiles

CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl.Cl

Molecular Formula

C31H29Cl2N7O2

Molecular Weight

602.51

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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