Palmatine hydroxide
Product Specifications
CAS Number
131-04-4
Target
Others, Apoptosis, Indoleamine 2,3-Dioxygenase (IDO), IDO, AChR, Aurora Kinase, Parasite, Antibacterial, Virus Protease
Related Pathways
Apoptosis, Neuroscience, Metabolism, Others, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Microbiology/Virology
Bioactivity
Palmatine hydroxide is an orally active, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), demonstrating IC50 values of 3 μM for HEK 293-hIDO-1 and 157μM for rhIDO-1. Additionally, it uncompetitively inhibits the West Nile virus (WNV) NS2B-NS3 protease with an IC50 of 96 μM. This compound exhibits a range of biological activities, including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects.
Smiles
[OH-].O(C=1C=CC2=CC=3C4=CC(OC)=C(OC)C=C4CC[N+]3C=C2C1OC)C
Molecular Formula
C21H23NO5
Molecular Weight
369.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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