SIRT6 activator 12q
Product Specifications
CAS Number
2601734-99-8
Target
Apoptosis|||Sirtuin|||Others
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair|||Others
Bioactivity
SIRT6 activator 12q is a potent, selective, and orally active compound that activates SIRT6. It demonstrates IC50 values of 171.20 ?M for SIRT1, >200 ?M for SIRT2, SIRT3, and SIRT5, and 0.58 ?M for SIRT6, indicating its high specificity towards SIRT6. This compound effectively inhibits cell growth and migration, induces apoptosis, and causes cell cycle arrest at the G2 phase, showcasing its anticancer activity.
Smiles
C(NC(C1=CC=CC=C1)C2=CC=CC=C2)(=O)C=3C4=C(N=C(C3)C5=CC=6C(O5)=CC=CC6)C=CC=C4
Molecular Formula
C31H22N2O2
Molecular Weight
454.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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