MTK458
Product Specifications
CAS Number
2499962-58-0
Target
Mitochondrial Metabolism, Mitophagy, PTEN
Related Pathways
Metabolism, Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9836
Bioactivity
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
Smiles
N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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