Tofacitinib Prodrug-1
Product Specifications
Target
Others, Apoptosis, JAK
Related Pathways
JAK/STAT signaling, Others, Tyrosine Kinase/Adaptors, Apoptosis, Chromatin/Epigenetic, Angiogenesis, Stem Cells
Bioactivity
Tofacitinib Prodrug-1 is an effective and oral active prodrug to mitigate the systemic adverse effects of Tofacitinib. Tofacitinib Prodrug-1 can effectively attenuate the oxazolone-induced colitis in mice model with low toxicity. Tofacitinib Prodrug-1 is a potential drug candidate for the treatment of ulcerative colitis .
Smiles
C[C@@H]1CCN(C(CC#N)=O)C[C@H]1CNC2=C3C=CN(C(N(CCCNC(OCC4=C(Cl)C=C(N=NC5=CC(C(O)=O)=C(O)C=C5)C=C4)=O)C)=O)C3=NC=N2
Molecular Formula
C36H39ClN10O7
Molecular Weight
759.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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