CEP-28122 mesylate salt
Product Specifications
Target
Others, ALK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others
Bioactivity
CEP-28122 mesylate salt, a diaminopyrimidine derivative, is a potent, selective, and orally bioavailable ALK (anaplastic lymphoma kinase) inhibitor with an IC50 value of 1.9 nM against recombinant ALK kinase activity. It shows antitumor efficacy in ALK-positive human cancer models and has favorable pharmacodynamic and pharmacokinetic profiles.
Smiles
COC1=C(C=CC2=C1CC[C@H](CC2)N3CCOCC3)NC4=NC=C(C(=N4)N[C@@H]5[C@@H]6C[C@H]([C@@H]5C(=O)N)C=C6)Cl.CS(=O)(=O)O
Molecular Formula
C29H39ClN6O6S
Molecular Weight
635.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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