TAK-960 dihydrochloride
Product Specifications
Target
Others, PLK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
TAK-960 dihydrochloride is an orally administered, selective polo-like kinase 1 (PLK1) inhibitor with a potent IC50 of 0.8 nM. It also targets PLK2 and PLK3 with IC50 values of 16.9 and 50.2 nM, respectively. This compound effectively inhibits the proliferation of a broad range of cancer cell lines and demonstrates substantial efficacy against various tumor xenografts.
Smiles
CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC.Cl.Cl
Molecular Formula
C27H36Cl2F3N7O3
Molecular Weight
634.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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