JBJ-09-063 hydrochloride
Product Specifications
Target
EGFR|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Others|||Angiogenesis
Bioactivity
JBJ-09-063 hydrochloride is an EGFR inhibitor selective for mutants, demonstrating IC50 values of 0.147 nM, 0.063 nM, 0.083 nM, and 0.396 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, and EGFR L747S, respectively. It effectively inhibits EGFR, Akt, and ERK1/2 phosphorylation, showing efficacy in both EGFR tyrosine kinase inhibitor (TKI) -sensitive and -resistant models. This compound holds potential for research on EGFR-mutant lung cancer.
Smiles
CN1CCC(CC1)C2=CC=C(C=C2)C3=CC4=C(CN(C4=O)C(C5=C(C=CC(=C5)F)O)C(=O)NC6=NC=CS6)C=C3.Cl
Molecular Formula
C31H30ClFN4O3S
Molecular Weight
593.11
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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