Nicotinamide Hydrochloride
Product Specifications
CAS Number
25334-23-0
Target
Others, Endogenous Metabolite, HBV, Sirtuin
Related Pathways
Others, DNA Damage/DNA Repair, Chromatin/Epigenetic, Metabolism, Microbiology/Virology
Bioactivity
Nicotinamide Hydrochloride, a form of vitamin B3 (niacin), inhibits sirtuin 2 (SIRT2) activity in vitro with an EC50 of 2 μM, reducing melanoma cell number by up to 90% and increasing cellular NAD+, ATP, and ROS levels. It also inhibits tumor growth in vivo and improves survival in melanoma-bearing mice, making it useful for skin cancer research, including melanoma.
Smiles
Cl.O=C(N)C=1C=NC=CC1
Molecular Formula
C6H7ClN2O
Molecular Weight
158.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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