Glucocorticoid receptor modulator 1
Product Specifications
CAS Number
2868357-11-1
Target
TNF|||DNA/RNA Synthesis|||Glucocorticoid Receptor|||MMP|||IL Receptor|||NF-?B
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Proteases/Proteasome|||NF-?B|||Endocrinology/Hormones|||Immunology/Inflammation|||DNA Damage/DNA Repair
Purity
0.9979
Bioactivity
Glucocorticoid receptor modulator 1 is a highly effective and orally administered NF-?B and AP-1 inhibitor with IC50 values of 9 nM and 130 nM, respectively. It can downregulate the expression of inflammatory factors IL-6, IL-1?, TNF-?, and MMP-13, thereby alleviating skin inflammation.
Smiles
O=C(C=1C=CC=CC1)N2C3=CC=C(C=C3CCC2)NS(=O)(=O)C=4C=C(Cl)C(=CC4OC)C
Molecular Formula
C24H23ClN2O4S
Molecular Weight
470.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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