FM04
Product Specifications
CAS Number
1807320-40-6
Target
P-gp
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Purity
0.9987
Bioactivity
FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2) . Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.
Smiles
O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3
Molecular Formula
C26H25NO4
Molecular Weight
415.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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