CDK8-IN-12
Product Specifications
CAS Number
2613307-67-6
Target
PKC, GSK-3, CDK
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Chromatin/Epigenetic
Purity
0.9983
Bioactivity
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
Smiles
O=C1C2(CCN(CC2)C=3C(=CN=CC3Cl)C4=CC=5C(O4)=CC=CC5)CCN1
Molecular Formula
C21H20ClN3O2
Molecular Weight
381.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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