CDK8-IN-12
Product Specifications
CAS Number
2613307-67-6
Target
PKC|||GSK-3|||CDK
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Chromatin/Epigenetic
Purity
0.9983
Bioactivity
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3?, GSK-3? and PCK-? with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
Smiles
O=C1C2(CCN(CC2)C=3C(=CN=CC3Cl)C4=CC=5C(O4)=CC=CC5)CCN1
Molecular Formula
C21H20ClN3O2
Molecular Weight
381.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/B2E8505D-948F-44CA-B52A-18D0F4C4C7B3/T72048
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
abx413438 100 µg
Killer Cell Lectin-Like Receptor Subfamily B Member 1 (KLRB1) Antibody (FITC)
Ask
View Details 
BNCB3249-500 1x 500 µL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/3249), Biotin conjugate, 0.1mg/mL
Ask
View Details ![Rabbit Polyclonal UVSSA Antibody [DyLight 550]](https://cdn.genprice.uk/genprice/genprice5.png)