β-Carboline-1-carboxylic acid
Product Specifications
CAS Number
26052-96-0
Target
IDO|||Indoleamine 2,3-Dioxygenase (IDO) |||NF-?B|||Others|||PDE|||Antibacterial
Related Pathways
Metabolism|||Others|||NF-?B|||Microbiology/Virology
Bioactivity
?-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-?, IL-6, and IL-1? levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-?1 in A549 cells. ?-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg/ml, respectively) . It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.
Smiles
OC(=O)c1nccc2c3ccccc3[nH]c12
Molecular Formula
C12H8N2O2
Molecular Weight
212.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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