Ambuic acid
Product Specifications
CAS Number
340774-69-8
Target
ERK, COX, JNK, Others, NO Synthase
Related Pathways
MAPK, Others, Neuroscience, Immunology/Inflammation
Bioactivity
Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when administered at a dose of 5 μg and decreases the activity of the agr quorum sensing system in an in vivo reporter assay.
Smiles
CCCCC\C=C\C1=C(CO)[C@@H](O)[C@H]2O[C@@]2(C\C=C(/C)C(O)=O)C1=O
Molecular Formula
C19H26O6
Molecular Weight
350.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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