Syntelin
Product Specifications
CAS Number
438481-33-5
Target
Kinesin, Others
Related Pathways
Cytoskeletal Signaling, Others
Bioactivity
Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.
Smiles
NC1=NC(SCC2=NN=C(SCC(O)=O)N2C2=CC=CC=C2)=NC2=C1C1=C(CCCC1)S2
Molecular Formula
C21H20N6O2S3
Molecular Weight
484.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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