Lobaric acid
Product Specifications
Target
Others|||Phosphatase|||Lipoxygenase|||TMV
Related Pathways
Metabolism|||Immunology/Inflammation|||Others
Bioactivity
Lobaric acid is a depsidone metabolite isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activities. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 ?mol), inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 ?g/ml), inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 ?M for the human recombinant enzyme), and inhibits production of 12 (S) -HETE [Item No. 34570] by 12 (S) -lipoxygenase (IC50 = 28.5 ?M) . In vivo, lobaric acid (250 ?M) reduces lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV) .
Smiles
C(CCCC)C1=C2C(OC(=O)C=3C(O2)=CC(OC)=CC3C(CCCC)=O)=CC(O)=C1C(O)=O
Molecular Formula
C25H28O8
Molecular Weight
456.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/7EF7A06D-BF72-4D72-90DC-FAB945883D52/T71811
CAS Number
522-53-2
Available Sizes
Curated Selection
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