SIM010603
Product Specifications
CAS Number
1032265-67-0
Target
Others|||c-Kit|||c-RET|||VEGFR
Related Pathways
Others|||Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-? (PDGFR-?), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC (50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-? and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
Smiles
O=C1/C(=C/2\C3=C(C(C(NCCN(C)C)=O)=C(C)N3)CCC2)/C=4C(N1)=CC=C(F)C4
Molecular Formula
C22H25FN4O2
Molecular Weight
396.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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