ARN 14494
Product Specifications
CAS Number
1037837-27-6
Target
NO Synthase, COX, Apoptosis, Interleukin, Others
Related Pathways
Apoptosis, Immunology/Inflammation, Neuroscience, Others
Bioactivity
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM) . ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
Smiles
O=C1N(C=2C(C1)=CC(C(NC)=O)=CC2)C3CCN(CC(=O)N4CC5C(C4)CCC5)CC3
Molecular Formula
C24H32N4O3
Molecular Weight
424.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4497507 1.0 µg DNA
Flad1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details GTR15220998 1 Vial
Lentiviral mouse Zbtb39 shRNA (UAS) - Lentiviral mouse Zbtb39 shRNA (UAS) (100)
Sign In for Pricing
View Details