ARN 14494
Product Specifications
CAS Number
1037837-27-6
Target
NO Synthase|||COX|||Apoptosis|||Interleukin|||Others
Related Pathways
Apoptosis|||Immunology/Inflammation|||Neuroscience|||Others
Bioactivity
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM) . ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against ?-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
Smiles
O=C1N(C=2C(C1)=CC(C(NC)=O)=CC2)C3CCN(CC(=O)N4CC5C(C4)CCC5)CC3
Molecular Formula
C24H32N4O3
Molecular Weight
424.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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