NSC145366
Product Specifications
CAS Number
1052515-37-3
Target
Others
Related Pathways
Others
Bioactivity
NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119μM) but does not compete with NTD or CTD-ATP binding.
Smiles
C(C)(C)(C1=CC=C(OCC(CNC(CC(C)(C)C)(C)C)O)C=C1)C2=CC=C(OCC(CNC(CC(C)(C)C)(C)C)O)C=C2.Cl
Molecular Formula
C37H63ClN2O4
Molecular Weight
635.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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