LEQ-506
Product Specifications
CAS Number
1057677-92-5
Target
Hedgehog/Smoothened, Others
Related Pathways
GPCR/G Protein, Others, Stem Cells
Bioactivity
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh) -ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.
Smiles
C(C=1C2=C(C(=NN1)N3CCN(CC3)C4=CC=C(C(C)(C)O)C=N4)C=CC=C2)C5=CC=CC=C5
Molecular Formula
C27H29N5O
Molecular Weight
439.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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