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LEQ-506

Product Specifications

CAS Number

1057677-92-5

Target

Hedgehog/Smoothened, Others

Related Pathways

GPCR/G Protein, Others, Stem Cells

Bioactivity

LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh) -ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.

Smiles

C(C=1C2=C(C(=NN1)N3CCN(CC3)C4=CC=C(C(C)(C)O)C=N4)C=CC=C2)C5=CC=CC=C5

Molecular Formula

C27H29N5O

Molecular Weight

439.55

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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