MF-592
Product Specifications
CAS Number
1064195-48-7
Target
Others, Prostaglandin Receptor
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Others
Bioactivity
MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM) . In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day) .. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development.
Smiles
O(CC)C1=C2C(=C(OCC)C=3C1=CC=CC3)CN(C2=O)C4=C(C)C=C(CC5(NC(NS(=O)(=O)C6=C(Cl)C=CC=C6Cl)=O)CC5)C=C4
Molecular Formula
C34H33Cl2N3O6S
Molecular Weight
682.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6265480-01 0.1 mL
Keratin 18 (Keratin Type I Cytoskeletal 18, Keratin-18, K18, KRT18, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-18, CK-18, CYK18, PIG46) (MaxLight 750)
Sign In for Pricing
View Details MBS6265480-02 5x 0.1 mL
Keratin 18 (Keratin Type I Cytoskeletal 18, Keratin-18, K18, KRT18, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-18, CK-18, CYK18, PIG46) (MaxLight 750)
Sign In for Pricing
View Details 