WRR-483
Product Specifications
CAS Number
1076088-50-0
Target
Others|||Parasite
Related Pathways
Others|||Microbiology/Virology
Bioactivity
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.
Smiles
[C@@H](NC(=O)N1CCN(C)CC1)(C(N[C@H](C=CS(=O)(=O)C2=CC=CC=C2)CCC3=CC=CC=C3)=O)CCCNC(=N)N
Molecular Formula
C29H41N7O4S
Molecular Weight
583.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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