RO314724
Product Specifications
CAS Number
112105-54-1
Target
Others
Related Pathways
Others
Bioactivity
RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.
Smiles
[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)(C(N[C@H](C(OCC)=O)C)=O)CC(C)C
Molecular Formula
C19H35N3O6
Molecular Weight
401.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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