RO5126946
Product Specifications
CAS Number
1137233-79-4
Target
Others
Related Pathways
Others
Bioactivity
RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.
Smiles
N(C(=O)C1=C(OC)C=CC(Cl)=C1)[C@H]2[C@@H](C2(C)C)C3=CC=C(S(N)(=O)=O)C=C3
Molecular Formula
C19H21ClN2O4S
Molecular Weight
408.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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