CHS-828 nicotinate
Product Specifications
CAS Number
1160589-73-0
Target
Others, NAMPT, Apoptosis
Related Pathways
Apoptosis, Metabolism, Others
Bioactivity
CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.
Smiles
C(O)(=O)C=1C=CC=NC1.N(=C(NCCCCCCOC1=CC=C(Cl)C=C1)NC#N)C=2C=CN=CC2
Molecular Formula
C25H27ClN6O3
Molecular Weight
494.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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