Flufenamic Acid-d4
Product Specifications
CAS Number
1185071-99-1
Target
Parasite, AMPK, COX, Potassium Channel, Chloride channel, Calcium Channel
Related Pathways
Metabolism, Chromatin/Epigenetic, Neuroscience, PI3K/Akt/mTOR signaling, Microbiology/Virology, Immunology/Inflammation, Membrane transporter/Ion channel
Bioactivity
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 μM for human COX-1 and COX-2, respectively) . Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 μM, respectively. Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1) . It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR) . Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice ......
Smiles
N(C1=C(C(O)=O)C(=C(C(=C1[2H])[2H])[2H])[2H])C2=CC(C(F)(F)F)=CC=C2
Molecular Formula
C14H6D4F3NO2
Molecular Weight
285.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
