Opaganib HCl
Product Specifications
CAS Number
1185157-59-8
Target
Others, S1P Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2.
Smiles
C(NCC=1C=CN=CC1)(=O)C23CC4(CC(C2)CC(C4)C3)C5=CC=C(Cl)C=C5.Cl
Molecular Formula
C23H26Cl2N2O
Molecular Weight
417.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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