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DS-1558

Product Specifications

CAS Number

1202575-67-4

Target

Others, GRK

Related Pathways

Others, GPCR/G Protein

Bioactivity

DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

Smiles

C(F)(F)(F)C1=C2C([C@H](OC3=CC=C([C@H](CC(O)=O)OCC)C=C3)CC2)=CC=C1

Molecular Formula

C21H21F3O4

Molecular Weight

394.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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