Foretinib phosphate
Product Specifications
CAS Number
1226999-07-0
Target
C-Met/HGFR, VEGFR, Others
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others
Bioactivity
Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
Smiles
OP(O)(O)=O.OP(O)(O)=O.COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Molecular Formula
C34H40F2N4O14P2
Molecular Weight
828.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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