Poloxipan
Product Specifications
CAS Number
1239513-63-3
Target
Others, PLK, STAT
Related Pathways
Others, Cell Cycle/Checkpoint, JAK/STAT signaling, Stem Cells
Bioactivity
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1) ; 1.7 uM (Plk2) ; and 3 uM (Plk3) . Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
Smiles
O=C\1N2C(S/C1=C\C3=C(OC)C=CC(Br)=C3)=NC(=O)C(C)=N2
Molecular Formula
C14H10BrN3O3S
Molecular Weight
380.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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