SB-1578 citrate
Product Specifications
CAS Number
1262279-15-1
Target
Others
Related Pathways
Others
Bioactivity
SB-1578 citrate is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.
Smiles
OC(=O)CC(O)(CC(O)=O)C(O)=O.C(CN1CCCC1)Oc1ccc2cc1COC\C=C\COCc1ccc(o1)C1=CC=NC(N1)=N2
Molecular Formula
C32H38N4O11
Molecular Weight
654.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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Map2k4, CT (Map2k4, Jnkk1, Mek4, Mkk4, Prkmk4, Sek1, Serk1, Skk1, Dual specificity mitogen-activated protein kinase kinase 4, C-JUN N-terminal kinase kinase 1, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1) (Azide free) (HRP) discontinued
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