Bizelesin
Product Specifications
CAS Number
129655-21-6
Target
Others, DNA Alkylator/Crosslinker
Related Pathways
DNA Damage/DNA Repair, Others
Bioactivity
Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
Smiles
C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(NC(NC=5C=C6C(=CC5)NC(C(=O)N7C8=C([C@H](CCl)C7)C9=C(C(O)=C8)NC=C9C)=C6)=O)C4)C1)C=C(O)C%10=C2C(C)=CN%10
Molecular Formula
C43H36Cl2N8O5
Molecular Weight
815.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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