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S63845

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1[1].

Product Specifications

CAS Number

[1799633-27-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/S63845.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C(Cl)=C(OCCN1CCN(C)CC1)C=C2)=[C@@]2[C@]3=C(C4=CC=C(F)O4)SC5=NC=NC(O[C@H](CC6=C(OCC7=CC=NN7CC(F)(F)F)C=CC=C6)C(O)=O)=C53

Molecular Formula

C39H37ClF4N6O6S

Molecular Weight

829.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Kotschy A, et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016 Oct 27;538 (7626) :477-482.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Mcl-1

Available Sizes

Curated Selection

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