MI-888 free base
Product Specifications
CAS Number
1303607-59-1
Target
Others, MDM-2/p53
Related Pathways
Apoptosis, Others
Bioactivity
MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.
Smiles
C(C(C)(C)C)[C@H]1[C@@]2([C@H]([C@H](C(N[C@H]3C[C@@](C)(O)C3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5
Molecular Formula
C28H32Cl2FN3O3
Molecular Weight
548.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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